_{the (g)old standard} Drug Targets - BASELINE ^{Created at 2021-05-14 11:28:35 UTC}

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt Q15878}

Molecular Functions ^{Source UniProt Q15878}

Reactome Pathways ^{Source UniProt Q15878}

R-HSA-112308, Presynaptic depolarization and calcium channel opening
R-HSA-422356, Regulation of insulin secretion

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P19022}

Molecular Functions ^{Source UniProt P19022}

Reactome Pathways ^{Source UniProt P19022}

R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-418990, Adherens junctions interactions
R-HSA-525793, Myogenesis
R-HSA-8957275, Post-translational protein phosphorylation

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P12277}

Molecular Functions ^{Source UniProt P12277}

Reactome Pathways ^{Source UniProt P12277}

R-HSA-71288, Creatine metabolism

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt Q96KS0}

Molecular Functions ^{Source UniProt Q96KS0}

Reactome Pathways ^{Source UniProt Q96KS0}

R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P01308}

Molecular Functions ^{Source UniProt P01308}

Reactome Pathways ^{Source UniProt P01308}

R-HSA-210745, Regulation of gene expression in beta cells
R-HSA-264876, Insulin processing
R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin
R-HSA-422356, Regulation of insulin secretion
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713, IRS activation
R-HSA-74749, Signal attenuation
R-HSA-74751, Insulin receptor signalling cascade
R-HSA-74752, Signaling by Insulin receptor
R-HSA-77387, Insulin receptor recycling
R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-977225, Amyloid fiber formation

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt O75914}

Molecular Functions ^{Source UniProt O75914}

Reactome Pathways ^{Source UniProt O75914}

R-HSA-202433, Generation of second messenger molecules
R-HSA-389359, CD28 dependent Vav1 pathway
R-HSA-3928664, Ephrin signaling
R-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-428540, Activation of RAC1
R-HSA-5218920, VEGFR2 mediated vascular permeability
R-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-5627123, RHO GTPases activate PAKs
R-HSA-5687128, MAPK6/MAPK4 signaling

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt Q9P286}

Molecular Functions ^{Source UniProt Q9P286}

Reactome Pathways ^{Source UniProt Q9P286}

R-HSA-428540, Activation of RAC1

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt O95153}

Molecular Functions ^{Source UniProt O95153}

Reactome Pathways ^{Source UniProt O95153}

R-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-196108, Pregnenolone biosynthesis
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P07202}

Molecular Functions ^{Source UniProt P07202}

Reactome Pathways ^{Source UniProt P07202}

R-HSA-209968, Thyroxine biosynthesis

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P05091}

Molecular Functions ^{Source UniProt P05091}

Reactome Pathways ^{Source UniProt P05091}

R-HSA-380612, Metabolism of serotonin
R-HSA-71384, Ethanol oxidation

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P04083}

Molecular Functions ^{Source UniProt P04083}

Reactome Pathways ^{Source UniProt P04083}

R-HSA-416476, G alpha (q) signalling events
R-HSA-418594, G alpha (i) signalling events
R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-445355, Smooth Muscle Contraction
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P54687}

Molecular Functions ^{Source UniProt P54687}

Reactome Pathways ^{Source UniProt P54687}

R-HSA-70895, Branched-chain amino acid catabolism

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt Q13489}

Molecular Functions ^{Source UniProt Q13489}

Reactome Pathways ^{Source UniProt Q13489}

R-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5357905, Regulation of TNFR1 signaling
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5668541, TNFR2 non-canonical NF-kB pathway
R-HSA-5675482, Regulation of necroptotic cell death
R-HSA-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
R-HSA-5689880, Ub-specific processing proteases
R-HSA-937041, IKK complex recruitment mediated by RIP1

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P16070}

Molecular Functions ^{Source UniProt P16070}

Reactome Pathways ^{Source UniProt P16070}

R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-216083, Integrin cell surface interactions
R-HSA-2160916, Hyaluronan uptake and degradation
R-HSA-6798695, Neutrophil degranulation
R-HSA-877300, Interferon gamma signaling

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P02795}

Molecular Functions ^{Source UniProt P02795}

Reactome Pathways ^{Source UniProt P02795}

R-HSA-5661231, Metallothioneins bind metals
R-HSA-877300, Interferon gamma signaling

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P25774}

Molecular Functions ^{Source UniProt P25774}

Reactome Pathways ^{Source UniProt P25774}

R-HSA-1236977, Endosomal/Vacuolar pathway
R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-1679131, Trafficking and processing of endosomal TLR
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295, MHC class II antigen presentation
R-HSA-6798695, Neutrophil degranulation

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P19875}

Molecular Functions ^{Source UniProt P19875}

Reactome Pathways ^{Source UniProt P19875}

R-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
R-HSA-6783783, Interleukin-10 signaling

10 best STRING interaction

PARAMTERS:

• the style of edges in the network: evidence;
• network type: physical;
• threshold of significance to include an interaction, a number between 0 and 1000: 900

Subcellular Location ^{Source UniProt P25025}

Molecular Functions ^{Source UniProt P25025}

Reactome Pathways ^{Source UniProt P25025}

R-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
R-HSA-6798695, Neutrophil degranulation